Indication: Long-term treatment of blood-flow disorders of the coronary vessels (coronary heart disease), Long-term
treatment and prophylaxis of angina pectoris, Treatment of severe myocardial insufficiency (choronic heart failure)
in combination with cardiac glycosedes, diuretics, ACE inhibitors, arterial vasodilators.
Dosage & Administration: One capsule once daily.
Contraindication & Precaution: Acute myocarkial infarction with low filling pressure, acute circulatory failure,
shock, vascular collapse, or very low blood pressure, known sensitivity to nitrates, marked anaemia, head trauma,
cerebral haemorrhage, severe hypotension or hypovolaemia.
Side Effect: Headache may occur at the start of treatment, but this usually disappears after a few days. Symptoms of
circulatory collapse may arise after the first dose in patients with labile circulation. Symptoms of postural
hypotension and syncope may result in some patients. Infrequently nausea, vomiting, flushing and allergic rashes can
Drug Interaction: Beta-blockers, calcium antagonists, vasodilators, alcohol, ACE inhibitors, sildenafil,
neuroleptics and tricyclic antidepressants.
Use in Pregnancy and Lactation: There is inadequate evidence of safety of the drug in human pregnancy but nitrates
have been used widely in the treatment of angina for many years without apparent ill consequence; animal studies
having shown no hazard. Nevertheless it is not advisable to use this drug during pregnancy and lactation.
Preparation: 50 mg LA (Long Acting) Capsule.