Aluminium Hydroxide, Magnesium Hydroxide & Simethicone

Indication: Hyperacidity, peptic ulcer, gastritis, peptic oesophagitis, gastric hyperacidity, heartburn, sour

stomach or hiatus hernia.
Dosage and Administration: 1-2 tablets/1-2 teaspoonful suspension 1-3 hours after meal and at bed time.
Contraindication and Precaution: Renal failure or Hypophosphataemia, alkalosis, hypermagneseamia.
Side Effect: Diarrhea, constipation or regurgitation.
Preparation: Tablet and Suspension (200 ml).

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Aluminium Hydroxide & Magnesium Hydroxide

Indication: Hyperacidity, peptic ulcer, gastritis, heartburn, sour stomach and dyspepsia.
Dosage and Administration: Two tablets/two teaspoonful suspension 1-3 hours after meal and at bed time.
Contraindication and Precaution: Hypophosphataemia, hypermag-neseamia.
Side Effect: Long term use may cause alkaluria, & nephrolithiasis.
Preparation: Tablet and Suspension (200 ml)

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Pivmecillinam

Indication: For treatment of infections caused by mecillinam-sensitive organisms, e.g. acute cystitis, complicated

urinary tract infections, salmonellosis, shigellosis, enteropathic E, coli diarrhoea, gram-negative septicaemia,

billiary infections.
Dosage and Administration: Adults : The usual dose is 1-2 tablets 3 times daily according to severity of the

infection, Children : weighing less than 20 kg should be given 20-60 mg/kg divided into 3-4 daily doses. Those

weighing more than 20 kg should receive normal adult dose. The tablet should be taken with at least 50-100 ml fluid.
Contraindication and Precaution: There have been no reports on allergy to Pivmecillinam among patients with a known

history of hypersensitivity to penicillins and cephalosporins.
Side Effect: Generally well tolerated, gastrointestinal disturbances such as nausea, vomiting and diarrhoea or

indigestion may occur when a dose has been given on an empty stomach. Skin rashes have been reported in some cases.
Use in Pregnancy and Lactation: Pivmecillinam in pregnancy should be prescribed when the expected benefits are

considered to be greater than the potential risk. Mecillinam is not excreted into the milk of lactating mother.
Preparation: 200 mg Tablet.

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Donepezil

Indication: Indicated for the treatment of mild to moderate dementia of the Alzheimer’s type.
Dosage and Administration: 5-10 mg once per day in the evening just prior to retiring. Treatment with a dose of 10

mg should be contemplated until patients have been on a daily dose of 5 mg for 4 to 6 weeks.
Contraindication and Precaution: Hypersensitivity to Donepezil hydrochloride or to piperidine derivatives.
Side Effect: The most common adverse events include nausea, diarrhea, insomnia, vomiting muscle cramp, fatigue and

anorexia.
Use in Pregnancy and Lactation: Donepezil should be used during pregnancy only if the potential benefit justifies

the potential risk to the fetus. Donepezil has no indication for use in nursing mothers.
Preparation: 5 mg Tablet.

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Carvedilol

Indication: Mild or moderate heart failure of ischemic or cardiomyopathic origin, in conjunction with digitalis,

diuretics and ACE inhibitors, Hypertension: Monotherapy or in combination.
Dosage and Administration: Initially 12.5 mg once daily, increased to 25 mg once daily; max. 50 mg daily

single/divided doses.
Contraindication: Severe chronic cardiac failure requiring intravenous inotropic therapy, bronchial asthma or

related bronchospastic conditions, second or third-degree AV block, sick sinus syndrome (unless a permanent

pacemaker is in place), cardiogenec shock, or severe bradycardia, use in hepatic impairment is not recommended.

Carvedilol is contraindicated in patients with hypersensitivity to the drug.
Side Effect: Postural hypotension, dizziness, headache, fatigue, gastro-intestinal disturbances, bradycardia,

occasionally diminished peripheral circulation, peripheral oededma and painful extremities, dry mouth, dry eyes, eye

irritation or disturbed vision, impotence, disturbances of micturition, influenza like symptoma, rarely angina.
Drug Interaction: Drug interaction have been seen with co-administration of carvedilol and digoxin.
Use in Pregnancy and Lactation: Not recommended.
Preparation: 6.25 mg, 12.5 mg and 25 mg Tablet.

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Doxycycline

Indication: Respiratory tract infections, genitourinary tract infections, lymphogranuloma venereum, trachoma,

brucellosis, tularemia, cholera, travelers dearrhea, acne, actinomycosis, yaws, relapsing fever, leptospirosis,

typhus, rickettsial Pox and Q fever, cellulitis furunculosis.
Dosage and Administration: 1 capsule every 12 hourly for the first day followed by 1 capsule per day. Children : 2.2

mg/kg daily.
Contraindication and Precaution: Hypesensitivity, severe hepatic disorder. Doxycycline should not be used in

pregnant women unless clearly needed.
Side Effect: Epigastric destress, abdominal discomfort, nausea, vomiting, skin rashes, urticaria, exfoliative

dermatitis.
Drug Interaction: Should not be taken with antacids, milk, other alkalis e.g. calcium, magnesium and iron,

penicillin, anticoagulants, anti-diabetic agents, anti-convulsants and enxyme inducing drugs.
Use in Pregnancy and Lactation: The drug should be avoided in nursing mothers and during the first trimester of

pregnancy. Doxycycline is not recommended in neonates.
Preparation: 100 mg Capsule.

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Diltiazem

Indication: Angina pectoris, Hypertension with tachycardia.
Dosage and Administration: 90-120 mg twice daily upto 240 mg.
Contraindication and Precaution: Known hypersensitivity, sick sinus syndrome, second or third degree AV block,

severe hypertension or acute myocardial infarction and pulmonary congestion.
Side Effect: Bradycardia, sino-atrial block, atrioventricular block, hypertension, malaise, headache, hot flushes,

GIT disturbances, oedema, hepatitis and depression reported.
Drug Interaction: Caution and careful dosage titration when diltiazem is administered concomitantly with other drugs

that can affect cardiac contractility and/or conduction.
Use in Pregnancy and Lactation: The drug should be used during pregnancy only when the potential benefits justify

the possible risk to the fetus. Women receiving the drug should not breastfeed their infants.
Preparation: 90 mg SR Tablet.

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Duloxetine

Dosage and Administration: Initial Treatment- Major Depressive Disorder. Total dose of 40 mg\day (given a 20 mg BID)

to 60 mg/day (given either once a day or as 30 mg BID) without regard to meals. Diabetic Peripheral Neuropathic

Pain. Total dose of 60 mg/day given once a day, without regard to meals.
Contraindication and Precaution: Known hypersensitivity to Duloxetine. Concomitant use in patients taking monoamine

oxidase inhibitors (MAOIs) is contraindicated. Duloxetine use should be avoided in patients with uncontrolled

narrow-angle glaucoma.
Side Effect: In Duloxetine-treated MDD patients: nausea; dry mouth; constipation; decreased appetite/ somnosence;

and increased sweating. In Duloxetin-treated DPN patients: nausea; somnolence; dizziness; constipation; dry mouth;

decreased appetite; and asthenia.
Precaution & Warning: Duloxetine increases the risk of elevation of serum transaminase levels. Because it is

possible that Duloxetine and alcohol may interact to cause liver injury. Duloxetine should ordinarily not be

prescribed to patients with substantial alcohol use. Blood pressure should be measured prior to intiating treatment

and periodically measured throughout treatment. Duloxeting should be used cautiously in patients with a history of

mania. Duloxetine should be prescribed with care in patients with a history of a seizure disorder.
Drug Interaction: Inhibitors of CYP1A2-fluvoxamine, quinolone antibiotics CYP2D6 inhibitors (e.g. Paroxetine,

fluoxetine, quinidine), Thioridazine, alcohol & other CNS acting drugs.
Use in Pregnancy and Lactation: The drug should be used during pregnancy only when the potential benefits justify

the possible risk to the fetus. Women receiving the drug should not breastfeed their infants.
Preparation: 60 mg DR (Delayed Release) Capsule.

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Glibenclamide

Indication: Non insulin dependent diabetes melitus (NIDDM).
Dosage and administration: Half tablet (2.5 mg) to 3 tablets. Daily doses as directed by the physician and depending

on blood sugar level.
Contraindication & Precaution: Severe metabolic de-compensation with acidosis, pre-comatose states and diabetic

coma, severe renal or hepatic dysfunction or serious impairment of typhoid or adrenal function; pregnancy, diabetes

mellitus complicated by fever, trauma or gangrene.
Side Effect: Nausea, vomiting, epigastric pain, dizziness, weakness, paraesthesia and headache. Allergic skin

reactions and haemopoietic reactions (leukopenia, thrombocytopenia, etc.)
Drug Interaction: Alcohol, cyclophosphamide, dicoumarol, monoamino oxidase inhibitors, phenylbutazone, propranolol

and other beta-adrenergic blocking agents.
Use in Pregnancy and Lactation: There is no information on the use of glibenclamide in human pregnancy.
Preparation: 5 mg Tablet.

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Clobetasol Propionate

Indication: Eczema, psoriasis, Hypertrophic lichen planus, Localized bullous disorders, Kelod scarring, Pretibial

myxoedema, Vitilligo, Susppression of reaction after cryotherapy.
Dosage and administration: Once or twice daily until improvement occurs, should not be continued for more than four

weeks.
Contraindication & Precaution: Impetigo, tinea corporis and herpes simplex, scabies, Acne vulgaris, Rssacea,

Gravitational ulceration.
Side Effect: Adrenal suppression, Prolonged and intensive treatment with a highly active corticosteroid preparation

may cause atrophic changes, such as thinning, striae and dilatation of the superficial blood vessels.
Drug Interaction: Clobetasol propionate should be avoided in pregnant women.
Use in Children: Should not be used children below the age of 12 years.
Preparation: 0.05% Cream and Ointment.

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