Cefixime

Indication: Urinary tract infections, upper and lower respiratory tract

infections, acute otitis media, gonococcal urethritis and enteric

fever.
Dosage and Administration: 200-400 mg as a single dose or in 2

divided doses daily for 7-14 days, Child dose : 8 mg/kg daily as a

single dose or in two divided doses for 7-14 days.
Contraindication and Precaution: Known hypersentivity to

Cephalosporin group of drugs.
Side Effect: Diarrhoea, nausea, abdominal pain, dyspepsia,

vomiting, flatulence, headache and dizziness.
Use in Pregnancy and Lactation: Cefixime should not be used in

pregnancy or in nursing mothers unless considered essential by

the physician.
Preparation: 200 mg Capsule, 400 mg Capsule 100 mg/5 ml

Suspension (30 ml, 40 ml, 50 ml).

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Vitamin C (Ascorbic acid)

Indication: Treatment or prevention of Vitamin C Deficiency.

Scurvy, Infection, Trauma, Burns, Cold exposure, Following

Surgery, Fever, Stress, Cancer, Methaemoglobinaemia and

Children receivieng unfortified formulas. Also indicated in

Hematuria, Dental Caries, Gum Diseases, Pyorrhea, Acne,

Infertility, Atherosclerosis, Fractures, Leg ulcers, Hay fever,

Vascular thrombosis prevention, Levodopa toxicity, Arsenic toxicity

and etc.
Dosage and Administration: One tablet daily with a meal or as

directed by physician. Dissolve one tablet in half glass (100 ml) of

water and drink instantly.
Contraindication and Precaution: There is no serious

contraindication to the administraion of Vitamin C. Diabetes,

patients prone to recurrent renal calculi and those on sodium

restricted or anticoagulant therapy should not take excessive

doses of ascorbic acid over an extended period of time.
Side Effect: Generally ascorbic acid is well tolerated. However, few

side effects including stomach upset, diarrhea, mouth sores or

frequent urination may be seen.
Drug Interaction: Limited evidence suggests that ascorbic acid may

influence the intensity and duration of action of

byhydroxycoumarin.
Use in Pregnancy and Lactation: During pregnancy and lactation

usual dosage is safe. But an increased dose to 5 gm at a time may

cause abortion.
Preparation: Vitamin C 1000 mg Effervescent Tablet.

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Ascorbic acid and Sodium Ascorbate

Indication: Scurvy, pregnancy, lactation, infection, trauma, burns,

cold exposure, folowing surgery, fever, stress, peptic ulcer, cancer,

methaemoglobinaemia haematuria, dental caries, pyorrhea, acne,

infertility, atherosclerosis, fractures, leg ulcers, hay fever, vascular

thrombosis prevention, levodopa toxicity, succinyl-choline toxicity,

arsenic toxicity etc.
Dosage and Administration: 1-2 tablets daily.
Contraindication and Precaution: There is no serious

contraindicaion to the administration of Vitamin C.
Side Effect: Diarrhoea, hypeoxaluria may occur.
Drug Interaction: Limited evidence suggests that ascorbic acid may

influence the intensity and duration of action of

byhydroxycoumarin.
Use in Pregnancy and Lactation: The drug is safe in normal doses

in pregnant women, but a daily intake of 5 gm or more is reported

to have caused abortion. The drug may be taken safely during

lactation.
Preparation: 250 mg Tablets.

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Aspirin

Indication: Antithrombotic action, mediated through inhibition of

platelet activation, secondary prophylaxis following myocardial

infarction and unstable angina or cerebral transient ischemic

attacks.
Dosage and Administration: 150 mg at diagnosis and 75 mg daily

thereafter.
Contraindication: Hypersensitivity to aspirin,

hypoprothrombinaemia, haemophillia and peptic ulceration,

asthma.
Side Effect: Hypersensitivity, asthma, urate kidney stoes, chronic

gastro-intestinal blood loss, tinnitus, nausea and vomiting.
Drug Interaction: Oral anticoagulants, oral hypoglycemic,

phenytoin, probenecid, sulphonamides.
Use in Pregnancy and Lactation: Aspirin should be avoided during

the last 3 months of pregnancy. It should not be used by patients

who are breast feeding.
Preparation: 75 mg Tablet.

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Atenolol + Chlorhalidone

Indication: Treatment of hypertension.
Dosage and Administration: Initial dose should be one

Chlorthalidone 25 mg + Atenolol 50 mg (Cardipro(R) 50 Plus) tablet

once a day. If an optimal response is not achieved, the dosage

should be increased to one Chlorthalidone 25 mg + Atenolol 100

mg (Cardipro(R) 100 Plus) tablet once a day.
Contraindication and Precaution: Sinus bradycardia; heart block

greater than first degree; cardiogenic shock, overt cardiac failure

anuria; hypersensitivity to this product or to sulfonamide-derived

drugs. This combination may aggravate perigheral arterial

circulatory disorders. Periodic determination should be performed

at appropriate intervals. Patients should be observed for clinical

signs of fluid or electrolyte imbalance; ie, hyponatremia,

hypochloremic alkalosis, and hypokalemia.
Side Effect: Most adverse effects have been mild and transient.

The adverse effects observed for this combination are essentially

the same as those seen with the individual components.
Drug Interaction: Other antihypertensive agents, Catecholamine

depletor (e.g. reserpine).
Use in Pregnancy and Lactation: Pregnancy Category D. Caution

should be exercised when this combination is administered to a

woman who is berast-feeding.
Use in Pediatric Patients: Safety and effectiveness in pediatric

patients have not been established.
Preparation: (Atenolol 50 mg + Chlorthalidone 25 mg)/Tablet,

(Atenolol 100 mg + Chlorthalidone 25 mg)/Tablet.

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Atenolol

ndication: Hypertension, angina pectoris, cardiac arrhythmia,

myocardial infarction.
Dosage and Administration: Cardipro(R) 50 mg once daily, can be

raised to 100-200 mg.
Contraindication & Precaution: Second and third degree heart

block, Untreated heart failure, Cardiogenic shock.
Side Effect: Cold extremities, fatigue, vivid dreams, insomnia,

diarrhoea, constipation, impotence and paraesthesia.
Drug Interaction: Verapamil, Class 1 anti-arrhythmic drug (e.g.

disopyramide), Clonidine, Indomethacin.
Use in Pregnancy and Lactation: Recommended.
Preparation: 50 mg and 100 mg Tablet.

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Nystatin

Indication: Candidiasis.
Dosage and Administration: 1 ml of the suspension should be

dropped into the mouth four times daily.
Contraindication & Precaution: Hypersentivity.
Side Effect: Oral irritation or sensitization, nausea, diarrhoea,

gastrointestinal distress, nausea and vomiting, Rash, including

urticaria has been reported rarely.
Drug Interaction: Not known.
Use in Pregnancy and Lactation: Nystatin should be prescribed

during pregnancy only if the potential benefits to be derived

outweigh the possible risks involved; caution should be exercised

when Nystsatin is prescribed for nursing woman.
Preparation: 1 lac unit/1 ml Suspension.

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Amlodipine + Benazepril

Indication: Hypertension.
Dosage and Administration: Amlodipine is an effective treatment of hypertension in once-daily doses of 2.5-10 mg while benazepril is effective in doses of 10-80 mg.
Contraindication & Precaution: in patients who are hypersensitive to benazepril to any other ACE ingibitor, or to amlodipine. Impaired Renal Function: Should be used with caution in patients with severe renal disease. Patients with Congestive Heart Failure: calcium channel blockers should be used with caution in patients with heart failure. Patients with Hepatic Failure: In patients with impaired hepatic function, caution should be exercised when administering this combination to patients with severe hepatic impairment.
Drug Interaction: Diuretics, Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) or potassium supplements, Lithium.
Side Effect: Generally mild and transient. The most common reasons for discontinuation of therapy with this combination were cough. Body as a Whole: Asthenia and fatigue. CNS: Insomnia, nervousness, anxiety, tremor, and decreased libido. Dermatologic: Flushing, hot flashes, rash, skin nodule, and dermatitis. Digestive: Dry mouth, nausea, abdominal pain, constipation, diarrhea, dyspesia, and esophagitis. Metabolic and Nutritional: Hypokalemia. Musculokeleta: Back pain, musculoskeletal pain, cramps, and muscle cramps. Respiratory: Pharyngitis. Urogenital: Sexual problems such as impotence, and polyuria.
Use in Pregnancy and Lactation: Pregnancy Categories C (first trimester) and D (second and third trimesters). Nursing Mothers: It is recommended that nursing be discontinued while this combination is administered.
Preparation: (Amlodipine 2.5 mg + Benazepril HCI 10 mg)/Capsule, (Amlodipine 5 mg+ Benazepril HCI 10 mg)/Capsule, (Amlodipine 5 mg + Benazepril HCI 20 mg)/Capsule, (Amlodipine 10 mg + Benazepril HCI 20 mg)/Capsule.

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Amlodipine + Atenolol

Indication: Hypertension not controlled by monotherapy, Patients with angina pectoris & hypertension as co-existing diseases, Post MI, Refractory angina pectoris where nitrate therapy has failed.
Dosage and Administration: Initiated with a single dose of Amoldipine 5 mg + Atenolol 50 mg. Depending upon the therapeutic response, titration of the dosage is recommended. In elderly patients, it is advisable to initiate the therapy with amlodipine 5 mg + Atenolol 25 mg tablet.
Contraindication and precaution: Hypersensitivity to any of the component. Bronchospasm: The combination should be used with caution in patients with airway obstruction. Renal Impairment: Caution may be necessary if the creatinine clearance is less than 30ml/min. Hepatic impairment: Caution may be necessary in the use of the combination in patients with severe liver damage. Drug withdrawal: Any discontinuation should be gradual and under observation.
Drug Interaction: Disopyramide, Ampicillin, Oral antidiabetic and insulin.
Side Effect: Well tolerated. Overall side effects include fatigue, headache, edema, nausea, drowsiness, anxiety and depression.
Use in Pregnancy and Lactation: Pregnancy: The combination should be used during pregnancy only if the expected benefit outweighs the potential foetal risk. Lactation: Nursing mothers should not use the combination. If its use is considered necessary, breast feeding should be stopped.
Preparation: (Amlodipine 5 mg + Atenolol 50 mg)/Tablet, (Amlodipine 5 mg+ Atenolol 25 mg)/Tablet.

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Amlodipine

Indication: Hypertension, stable angina, vasospastic angina.
Dosage and Administration: 5-10 mg once daily.
Contraindication & Precaution: Known hypersentivity.
Side Effect: Headache, oedema, fatigue, nausea, flushing, dizziness, gum hyperplasia; erythema multiforme.
Drug Interaction: Digoxin, Warfarin, Cimetidine.
Use in Pregnancy and Lactation: Not recommended.
Preparation: 5 mg and 10 mg Tablet.

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