Clopidogrel+Aspirin

Indication: Prevention of atherosclerotic events in patients with history of symptomatic atherosclerotic diseases (ischemic stroke, myocardial infarction or acute coronary syndrome).
Dosage & Administration: Once daily.
Contraindication & Precaution: Hypersensitivity to any of the components or NSAIDs. Active pathological bleeding such as peptic ulcer or intracranial hemorrhage or bleeding disorders like hemophilia. Recent history of gastrointestinal bleeding.
Side Effect: Abdominal pain, nausea, vomiting, neuralgia, paresthyesia, rash, prututis.
Drug Interaction: This combination may enhance the effect of anticoagulants.
Use in Pregnancy and Lactation: The combination drug should be avoided during the last three months of pregnancy. It is not recommended for use during breast feeding because of the possible risk of developing Reye’s syndrome.
Use in Pediatric patients: Safety and effiacacy in the pediatric population have not been established.
Preparation: (Clopidogrel 75 mg+Aspirin 75 mg)/Tablet.

Posted in Uncategorized

Clopidogrel

Indication: Atherosclerotic disease (ischemic stroke, myocardial infarction or established peripheral arterial disease), prophylactically in patients at the risk of thrombo-embolic disorders such as myocardial infarction and stroke.
Dosage & Administration: One tablet once daily.
Contraindication & Precaution: Hypersensitivity, Active pathological bleeding such as peptic ulcer or intracranial hemorrhage.
Side Effect: Hemorrhage, abdominal discomfort, nausea, vomiting, diarrhoea, headache, dizziness, vertigo, paraesthesia, rash, pruritus, hepatic and biliary disorder, neutropenia may occur.
Drug Interaction: Aspirin, NSAIDs should be used with cautions to patients taking Clopidogrel.
Use in Pregnancy and Lactation: Clopidogrel should be used in pregnant women and nursing mothers only if clearly needed.
Preparation: 75 mg Tablet.

Posted in Uncategorized

Cefprozil

Indication:Skin and Skin Structure Infections, Upper Respiratory Tract Infections (including-Pharyngitis/Tonsillitis, Otitis Media, Acute Sinusitis). Lower Respiratory Tract Infections (including-Secondary Bacterial Infection of Acute Bronchitis, Acute Bacterial Exacerbation of Chronic Bronchitis, Pneumonia). Acute Uncomplicated Urinary Tract Infections.
Dosage & Administration: Cefprozil is administered orally.

Population/Infection Dosage (mg) Duration (days)
Infants & Children (6 months-12 years
Upper Respiratory Tract
Otitis Media 15 mg/kg q 12h 10
Acute Sinusitis
(For moderate to severe infections the higher dose should be used) 7.5 mg/kg q 12h or
15 mg/kg q 12h 10
Children (2-12 years)
Upper Respiratory Tract#
Pharyngitis/tonsillitis 7.5 mg/kg q 12h 10*
Skin & Skin Structure#
Uncomplicated Skin & Skin Structure Infections 20 mg/kg q 24h 10
Adults (13 years & older)
Upper Respiratory Tract
Pharyngitis/Tonsillitis 500 q 12h 10*
Acute Sinusitis
(For moderate to severe infections the higher dose should be used) 250 q 12h or
500 q 12h 10
Lower Respiratory Tract
Secondary Bacterial infection of Acute Bronchitis
& Acute Bacterial Exacerbation of Chronic Bonchitis 500 q 12h 10
Skin & Skin Structure
Uncomplicated Skin &
Skin Structure Infections 250 q 12h or
500 q 24h or 12h 10
*In the treatment of infections due to Streptococcus pyogenes. Cefprozil should be administered for at least 10 days.
# Not to exceed recommended adult doses.
Contraindication & Precaution: Known hypersensitivity to the Ciphalosporins or to any of the constituents of the preparations.
Side Effect: Diarrhea, vomiting, stomach pain and dizziness. Very rarely-severe skin rash, itching, difficulty in breathing or swallowing, wheezing, yellowing of the skin and eyes, painful sores in the mouth or throat, vaginal discharge and itching and diaper rash.
Drug Interaction: Aminoglycoside antibiotics and Probenecid.
Use in Pregnancy and Lactation: Pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Still during pregnancy the drug should be used according to physician’s recommendation.
Preparation: 250 mg and 500 mg Tablet, 250 mg/5 ml Suspension.

Posted in Uncategorized

Tramadol

Indication: Post-operative pain, Colic and spastic pain, Cancer pain, Joint pain, Neck and back pain, Pain associated with osteoporosis.
Dosage & Administration: Usual doses are 50-100 mg every four to six hours. For acute pain an initial dose of 100 mg is required.
Contraindication & Precaution: Hypersensitivity, acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids or psychotropic drugs. When large doses of Tramadol are administered with anaesthitic medications or alcohol, respiratory depression may result. Tramadol should be used with caution in patients with increased intracranial pressure or head injury and patients with acute abdominal conditions.
Side Effect: Dizziness/vertigo, nausea, constipaton, headache, somnolence, vomiting, pruritus, CNS stumulation asthenia, Less commonly occurring side-effects include malaise, allergic reaction, weight loss, vasodilatation, abdominal pain, anorexia, flatulence, GI bleeding, hepatitis, stomatitis etc.
Drug Interaction: Monoamine oxidase (MAO) inhibitors, Carbamazepine.
Use in Pregnancy and Lactation: Tramadol should be used during pregnancy only if the potential benefit justifies the risk to the foetus.
Use in Children: In children from the age of one year Tramadol can be given in a dose of 1-2 mg/kg body weight.
Preparation: 50 mg Capsule, 100 mg/2 ml Injection, 100 mg Suppository.

Posted in Uncategorized

Metronidazole

Indication: Amoebiasis, Trichomoniasis, Giardiasis, Bacterial vaginosis, Acute ulcerative gingivitis, Anaerobic inrections including septicaemia, bacteremia, peritonitis, brain abscess, necrotising pneumionioa, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitis, etc. Leg ulcers and pressure sores, Acute dental inrections, Surgical prophylaxis, Chronic symptomatic ulcer disease.
Dosage & Administration: Adults: 200-400 mg, every 8 hours, Children: 30-40 mg/kg/day in 3 divided doses.
Contraindication: Hypersensitivity to imidazole.
Side Effect: Metallic taste, furred tongue, nausea, vomiting, diarrhoea, drowsiness, rashes and mild reversible leukopenia, peripheral neuropathy.
Drug Interaction: Alcohol, nicoumalone and warfarin, phenytoin, phenobarbitone, fluorouracil, disulfiram, lithium and cimetidine.
Preparation: 400 mg Tablet, 200 mg/5 ml Suspension.

Posted in Uncategorized

Ambroxol

Indication: Productive cough, Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis, laryngitis, Phryngitis, sinusitis and rhinitis associated with viscid mucus, Asthmatic bronchitis, bronchial asthma with thick expectoration, Bronchiectasis, chronic pneumonia.
Dosage and administration: Average daily dose (preferably after meal): Paediatric Drops: 0-6 months old-0.5 ml, 2 times a day, 6-12 months old-1 ml, 2 times a day, 1-2 years old-1.25 ml, 2 times a day. Syrup: 2-5 years old-2.5 ml (1/2 teaspoonful), 2-3 times a day, 5-10 years old-5 ml (1 teaspoonful), 2-3 times a day, 10 years old and adults-10 ml (2 teaspoonful), 3 times a day. Ambrox(R) 75 SR Capsule: Adults and children over 12 years old-1 capsule, once daily.
Side Effect: Epigastric pain, stomach overfill feeling may occur occasionally. Rarely eruption, urticaria or angioneurotic edema has been reported.
Contraindication and Precaution: Known hypersensitivity to Ambroxol or Bromhexine. Should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.
Drug Interaction: Ambroxol should not by taken simultaneously with antitussives (e.g. Codeine).
Use in Pregnancy and Lactation: It is advised not to use in pregnancy, especially during the 1st trimester. Safety during lactation has not been established yet.
Preparation: 6 mg/ml Paediatric Drops, 15 mg/5ml Syrup, 75 mg SR Capsule.

Posted in Uncategorized