Clotrimazole

Indication: Dermatomycoses due to candida, trichophyton, moulds and other fungi, skin diseases showing superinfections with these funge e.g. Inter digital mycoses, paronychia, candida vulvitis, balanitis, pityriasis versicolor and erythrasma.
Dosage and Administration: 2-3 times daily.
Contraindication and Precaution: Hyperesensitivity to clotrimazole.
Side Effect: Local irritation or burning may occur in very few cases.
Use in Pregnancy: It is recommended that Clotrimazole should be used in pregnancy only when considered necessary by the physician.
Preparation: 10 mg/gm Cream.

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Diphenhydranmine

Indication: For the treatment of following: 1) Seasonal, perennial & vasomotor rhinitis, 2) urticaria, angioneurotic edema, anaphylaxis, 3) pruritus 4) preanesthetic medication, emesis, motion sickness, 5) miscellaneous including meniere’s diseases and parkinsonism, 6) cough & cold. Sometimes it may use as a night time sleep aid and for the short-term management of insomnia.
Dosage and Administration: Most allergic conditions are controlled with 25 to 50 mg i.e. (12.5 to 25 ml of syrup) 3 to 4 times a day. Children 6 to 12 years of age: 10 mg i.e. (5 ml of syrup) 3 to 4 times a day. Children 1 to 6 years of age: 5 mg i.e; (2.5 ml of syrup) 3 to 4 times a day. In motion sickness: Adult: 25 to 50 mg 3 to 4 times a day. Children (above 9.1 kg): 12.5 to 25 mg 3 to 4 times a day (5 mg/kg/24 hours). In parkinsoism:Adult: 25 to 50 mg 3 to 4 times a day. Children (above 9.1 kg): 12.5 to 25 mg 3 to 4 times a day (5 mg/kg/24 hours). In insomnia: Adults and children over 12 years of old : A dose of 20 to 50 mg is used as hypnotic in insomnia. In cough & cold: Adults: 25 mg every 4 hours. Not to exceed 150 mg in 24 hours. Children (6 to 12 years): 12.5 mg every 4 hours. Not to exceed 75 mg in 24 hours. Children (2 to 6 years): 6.25 mg every 4 hours.
Contraindication and Precaution: Contraindicated for the premature or newborn infants. Any patients in whom drowsiness is undesirable e.g. drivers, machine operators. Patients with known hypersensitivity to Diphenhydramine or any components of the product.patients should be cautioned not to operate vehicles or hazardous machinery until their response to the drug has been determined.
Drug lnteractiona: antituberculous agent, para-aminosalicylic acid (PAS), alcohol, other CNS depressants (hypnotics, sedatives, tranquilizers, etc), MAO inhibitors.
Side Effect: Side effects include drowsiness, dizziness, dryness of mouth, blurred vision, nausea and vomiting.
Uses in pregnancy & Lactation: Should be used in pregnancy only if clearly needed. Use in lactating mother is not recommended.
Preparation: 10 mg/5 ml Syrup.

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Efavirenz

Indication: In combinanation with other antiretroviral agents is indicated for the treatment of HIV infection.
Dosage and Administration: Adults: 600 mg orally, once daily, in combination with a protease inhibitor and/or nucleoside analogue reverse transcriptase inhibitors (NTTls). Pediatric Patients: Weighing greater than 40 kg is 600 mg, once daily.

Body weight (kg) Adiva(R) : Dose (mg)
10 to <15>40 600
Contraindication and Precaution: Contrindicated in patients with clinically significant hypresernsitivity to any of its components.
Warning: Efavirenz must not be used as a single agent to HIV-1 infection or added on as a sole agent to a failing regimen.
Adverse action & Precaution: Nervous System Symptoms: Dizziness, insomnia, impaired concentration, somnolence, abnormal dreams, and hallucinations. Psychiatric Symptoms: Severe depression, suicidal ideation, nonfatal suicide attempts, aggressive behavior, paranoid reactions, and manic reactions, Skin Rash, Pancreatitis and asymptomatic increses in serum auylase levels were observed in a significantly higher number of patients.
Drug Interaction: Efavirenz should bot be administered with Astemizole Cisapride, Midazolam, Triazolam, Ergot derivatives, Voriconazole.
Uses in Pregnancy & Lactation: Pregnancy category D. Efavirenz may cause fetal harm when administered during the first trimester. Pregnancy should be avoided n women receiving Efavirenz. Women of childbearing potential should undergo pregnancy testing before initiation of Efavirenz. Mothers should be instructed not to breast-feed if they are receiving Efavirenz.
Preparation: 600 mg Tablet.

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Cefdinir

Indication: Community Acquired Pneumonia, Acute Exacerbation

of Chronic Bronchitis, Acute Maxillary Sinusitis,

Pharyngitis/Tonsillitis, uncomplicated Skin and Skin structure

Infections.
Dosage and Administration: 600 mg as a single dose or in 2

divided dose daily for 5-10 days. Paediatric patients (6 months to

12 years): 14 mg/kg daily single dose or in 2 divided dose daily for

5-10 days.
Contraindication and Precaution: Known allergy to the

cephalosporins class of antibiotics.
Side Effect: Diarrhea or nausea.
Precaution: Prolonged treatment may result in the possible

emergence and overgrowth of resistant organisms. Cefdinir, as

with other broad spectrum anti-microbials (antibiotics), should be

prescribed with caution in individuals with a history of colitis. In

patients with transient or persistent renal insufficiency (creatinine

clearance <30 ml/min), the total daily dose of Cefdinir should be reduced.
Use in Pregnancy and Lactation: This drug should be used during

pregnancy only if clearly needed.
Preparation: 300 mg Capsule, 125 mg/5 ml Suspension.

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Parcetamol & Caffeine

Indication: Fever, headache, migraine, muscle ache, backache, toothache & menstrual pain.
Dosage & Administration: Adults: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily. Not recommended for children below 12 years.
Contraindication & Precaution: Hypersensitivity to paracetamol Caffeiner or any other components of it.
Side Effect: This combination may cause skin rashes, neutropenia & gastrointestinal disturbances etc. High dose administation may cause hepatotoxicity.
Uses in pregnancy & Lactation: Although there is epidemiological evidence of the safety of Paracetamol in pregnancy & lactation, medical advice should be sought before using this product.
Drug interaction: It increases the effect of chloramphenicol and coumarin anticoagulant. Risk of hepatotoxicity of paracetamol may be increased in alcoholics or in patients taking other anti-epilectic medications.
Precaution: Should be given cautiously in the following cases: In patients with hapatic or renal failure, in patients taking other hepatotoxic medication. Prolkonged use of the drug without consulting a physician should be avoided.
Preparation: Paracetamol 500 mg & Caffeine 65 mg.

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